Cognitive Behavioral Therapy is a form of talk therapy that helps individuals to become more aware of inaccurate or negative thought patterns or ways of thinking. The foundations of CBT are largely built upon the idea of Socratic Questioning, wherein the therapist will help the individual to explore complex ideas, open up issues and problems, analyze concepts, and look at our stressors through a different lens. 
Talk Therapy is an effective form of therapy, but it is generally not considered to be an effective treatment for DPDR. That being said, it can be effective for giving the individual an understanding of their symptoms if they are able to receive an accurate diagnosis.
- Some find CBT to be an effective form of treatment as it allows them to address impactful events that may be contributing to their symptoms and work through them. However, CBT has not been found to be a particularly effective method for treating DPDR.
- In a small, 21 patient study, only 29% (6) of the participants no longer met the criteria for DPD at the end of the therapy. The therapy involved helping the patients reinterpret their symptoms in a non-threatening way as well as reducing avoidances, safety behaviours and symptom monitoring. Improvements in patient-defined measures for DP/DR severity as well as standardised measures of dissociation, depression, anxiety and general functioning were found at post-treatment and six-months follow-up. This is only one, small study and further trials with larger sample sizes and more rigorous research methodology are needed.