There is no documented cure or treatment for DPDR Disorder, but a combination of medication has been shown to be effective in some cases. Specifically, a combination of Lamotrigine (Lamictal) and SSRIs has shown some effectiveness, but pharmaceutical interventions are still largely ineffective and more research is needed. Many have found that medicines will often exacerbate symptoms and result in further dulling of emotions and ineffective prescriptions are often prescribed due to the constant misdiagnosis of this disorder.
- Among the many psychoactive drugs studied, none of them has been shown to be the treatment of choice. Among those with which the best results are obtained are opioid receptor antagonists, the combination of selective-serotonin re-uptake inhibitors with lamotrigine and clorimipramine. 
- The limited data from randomised controlled trials on the pharmacotherapy and psychotherapy of DPRD demonstrates inconsistent evidence for the efficacy of lamotrigine, and no efficacy for other interventions. Additional research on this disorder is needed.